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Guy C Brown Selected Research

1- hydroxy- 2- oxo- 3,3- bis(2- aminoethyl)- 1- triazene

8/2009Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release.
5/2006Nitric oxide stimulates PC12 cell proliferation via cGMP and inhibits at higher concentrations mainly via energy depletion.
4/2005Nitric oxide from inducible nitric oxide synthase sensitizes the inflamed aorta to hypoxic damage via respiratory inhibition.
1/2005Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death.
12/2003Nitric oxide induces apoptosis via hydrogen peroxide, but necrosis via energy and thiol depletion.

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Guy C Brown Research Topics

Disease

18Necrosis
08/2014 - 12/2002
13Inflammation (Inflammations)
12/2021 - 04/2005
9Alzheimer Disease (Alzheimer's Disease)
01/2021 - 09/2006
8Hypoxia (Hypoxemia)
12/2015 - 06/2003
5Ischemia
02/2022 - 04/2003
4Neuroinflammatory Diseases
01/2022 - 02/2012
4Parkinson Disease (Parkinson's Disease)
10/2021 - 10/2013
4Neurodegenerative Diseases (Neurodegenerative Disease)
10/2021 - 01/2019
4Neoplasms (Cancer)
01/2021 - 08/2012
3Mitochondrial Diseases (Mitochondrial Disease)
08/2009 - 04/2003
2Brain Ischemia (Cerebral Ischemia)
02/2022 - 10/2013
2Stroke (Strokes)
02/2022 - 12/2021
2Memory Disorders (Memory Loss)
12/2021 - 09/2019
2Bacterial Infections (Bacterial Infection)
10/2021 - 09/2019
2Amyloid Plaque
01/2021 - 09/2006
2Burkitt Lymphoma (Burkitt's Lymphoma)
01/2019 - 09/2017
2Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell)
01/2019 - 09/2017
1Brain Infarction
02/2022
1Infarction (Infarctions)
02/2022
1Cardiovascular Diseases (Cardiovascular Disease)
01/2021
1Communicable Diseases (Infectious Diseases)
01/2021
1Immune System Diseases (Immune Disorders)
01/2021
1Mental Disorders (Mental Disorder)
01/2021
1Sepsis (Septicemia)
09/2019
1Liver Failure
09/2019
1Infections
09/2019
1Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
09/2019
1Acquired Immunodeficiency Syndrome (AIDS)
09/2019
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2019
1Lymphoma (Lymphomas)
01/2019
1Disease Progression
04/2015
1Traumatic Brain Injuries (Traumatic Brain Injury)
03/2014
1Atrophy
10/2013
1Obesity
10/2013

Drug/Important Bio-Agent (IBA)

10Nitric Oxide (Nitrogen Monoxide)FDA Link
06/2010 - 10/2003
7Proteins (Proteins, Gene)FDA Link
01/2021 - 08/2012
7CaspasesIBA
01/2013 - 04/2003
6Amyloid beta-PeptidesIBA
12/2021 - 09/2006
6LipopolysaccharidesIBA
10/2021 - 10/2006
5Adenosine Triphosphate (ATP)IBA
12/2021 - 12/2002
5Cytochromes c (Cytochrome c)IBA
01/2013 - 04/2003
5Oxygen (Dioxygen)IBA
06/2010 - 06/2003
51- hydroxy- 2- oxo- 3,3- bis(2- aminoethyl)- 1- triazeneIBA
08/2009 - 12/2003
3purinoceptor P2Y6IBA
02/2022 - 10/2021
3EndotoxinsIBA
10/2021 - 04/2005
3Amyloid (Amyloid Fibrils)IBA
09/2019 - 11/2011
3Glutamic Acid (Glutamate)FDA Link
01/2018 - 10/2007
3NADPH Oxidases (NAD(P)H oxidase)IBA
12/2016 - 09/2005
3Deoxyglucose (2 Deoxy D glucose)IBA
03/2014 - 01/2005
3Electron Transport Complex IV (Cytochrome c Oxidase)IBA
06/2010 - 06/2003
2CalreticulinIBA
01/2022 - 08/2012
2Complement System Proteins (Complement)IBA
12/2021 - 10/2018
2Opsonin Proteins (Opsonins)IBA
12/2021 - 10/2018
2Pattern Recognition ReceptorsIBA
01/2021 - 04/2015
2Galectin 3 (LGALS3)IBA
01/2020 - 01/2019
2SynucleinsIBA
09/2019 - 03/2014
2Peptides (Polypeptides)IBA
01/2019 - 09/2006
2ArginaseIBA
01/2019 - 04/2009
2Peroxynitrous Acid (Peroxynitrite)IBA
12/2015 - 06/2003
2Superoxides (Superoxide)IBA
12/2015 - 09/2005
2CytokinesIBA
08/2014 - 06/2010
2milk fat globuleIBA
10/2013 - 04/2011
2L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
08/2009 - 04/2005
2Nitric Oxide Synthase (NO Synthase)IBA
09/2005 - 04/2005
1Endothelin-1 (Endothelin 1)IBA
02/2022
1PhosphatidylserinesIBA
12/2021
1Sialic Acid Binding Immunoglobulin-like LectinsIBA
01/2021
1RNA (Ribonucleic Acid)IBA
01/2021
1LipidsIBA
01/2021
1N-Acetylneuraminic Acid (Sialic Acid)IBA
01/2021
1Apolipoproteins E (ApoE)IBA
09/2019
1Apolipoprotein E4IBA
09/2019
1CitrullineIBA
01/2019
1LigandsIBA
01/2019
1Asparaginase (Elspar)FDA Link
01/2019
1Arginine (L-Arginine)FDA Link
01/2019
1Cytotoxins (Cytolysins)IBA
01/2019
1EnzymesIBA
01/2019
1Chloroquine (Aralen)FDA LinkGeneric
01/2019
1ApolipoproteinsIBA
10/2018
1Oxidants (Oxidizing Agents)IBA
01/2018
1AntibodiesIBA
09/2017
1Protein Kinases (Protein Kinase)IBA
12/2016
1Protein Kinase CIBA
03/2014
1InterferonsIBA
03/2014
1Tetradecanoylphorbol AcetateIBA
03/2014
1Interleukin-4 (Interleukin 4)IBA
03/2014
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
10/2013
1Epidermal Growth Factor (EGF)IBA
10/2013
1c-Mer Tyrosine KinaseIBA
10/2013
1Factor VIII (Coagulation Factor VIII)IBA
10/2013
1Transfer RNA (tRNA)IBA
10/2013
1RotenoneIBA
10/2013
1PesticidesIBA
10/2013
1Caspase 8 (Caspase-8)IBA
03/2013
1isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketoneIBA
03/2013
1benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA
03/2013
1Anthocyanins (Anthocyanin)IBA
01/2013

Therapy/Procedure

2Therapeutics
01/2021 - 09/2017
1Axotomy
01/2018